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Doing business in Ohio subjects you to the Commercial Activities Tax (CAT), employee withholding, and sales and use taxes. Many of your questions can be answered by the Ohio Department of Taxation. For specific tax or legal advice, please consult an attorney or tax adviser.
SOUTH DAKOTA v. WAYFAIR, INC., ET AL.
US Supreme Court ruled on 6/21/18 that a state can require an out-of-state seller with no physical presence in the state to collect and remit sales taxes on goods the seller ships to consumers in the state.
CRUTCHFIELD CORP. v. TESTA, 2016-OHIO-7760
Ohio can impose its CAT business tax on out-of-state companies that sell to Ohioans but have no physical presence in the state.